Mikel Arteta makes one change to the side that started at Turf Moor eight days ago.
The Arsenal coach welcomes back Granit Xhaka after a three-match suspension as the Swiss midfielder replaces Nicholas Pepe.
It’s likely to trigger a slight change in setup with Xhaka likely to play alongside Thomas Partey, the one survivor from the midweek win over Wimbledon in the Carabao Cup.
It now looks like a 4-2-3-1 shape for the Gunners with Bukayo Saka, Martin Odegaard and Emile Smith Rowe playing behind captain Pierre-Emerick Aubameyang.
Arsenal goalkeeper Aaron Ramsdale, and two of the Gunners’ back four in Takehiro Tomyasu and Ben White are set to face Tottenham for the first time since moving to the Emirates.
Meanwhile, Spurs youngster Japhet Tanganga will make his first appearance in the North London derby, having been an unused substitute for the clubs’ clash at the Tottenham Hotspur Stadium last term.
It’s three changes for Spurs and Nuno Espirito Santo after defeat to Chelsea a week ago.
Two come in defence where Japhet Tanganga and Davinson Sanchez are favoured over the benched pair of Emerson Royal and Cristian Romero while Lucas Moura is back from injury and is selected ahead of Giovani Lo Celso.
It’s the same midfield trio of Tanguy Ndombele, Pierre-Emile Hojbjerg and Dele Alli for the visitors, who will again line-up in a 4-3-3 shape.